Trial A – Z
Y
Z
ATNEC
اقرأ المزيد
– The ATNEC trial is studying whether some patients can safely avoid further underarm (axillary) treatment after breast cancer surgery. This treatment usually includes surgery to remove lymph nodes or radiotherapy. The trial includes patients with early-stage breast cancer whose cancer had spread to lymph nodes, but after chemotherapy, no cancer is found during surgery.
– It compares standard treatment with no further treatment to the lymph nodes, to see if this is just as effective in preventing cancer returning while reducing side effects like arm swelling (lymphoedema) over five years.
POSNOC
اقرأ المزيد
– This study looks at whether some women with early breast cancer need extra surgery or radiotherapy in the armpit when only a small amount of cancer is found in 1 or 2 sentinel lymph nodes. All patients receive standard systemic therapy, and the trial compares outcomes between those who get additional axillary treatment and those who do not.
– The main goal is to see if skipping extra axillary treatment is just as safe in preventing cancer coming back in the armpit over five years, potentially reducing unnecessary surgery and its side effects.
TIP Trial
اقرأ المزيد
– This study is testing whether Rivaroxaban, a blood-thinning medication, can help slow the growth of early breast cancer before surgery. Research suggests that blood clotting can promote cancer growth, and anticoagulants may block this effect. Patients with estrogen receptor-negative breast cancer will take Rivaroxaban before surgery, and researchers will measure its impact by looking at Ki67, a marker of tumour cell growth, comparing levels before and after treatment.
– The goal is to see if Rivaroxaban can reduce tumour proliferation and potentially offer a new approach to treating breast cancer.
BIOSYM
اقرأ المزيد
– This study involves women having immediate breast reconstruction with an implant. They will be randomly assigned to receive either a biological mesh (ADM) or a synthetic mesh. The study will follow them for 6 months to see if patients and surgeons are comfortable not choosing the mesh type.
– In a larger future study, researchers will look at patient satisfaction, quality of life, complications, and costs over 5 years. Patients will attend follow-up visits at 3 and 6 months after surgery, where their recovery and experiences will be recorded using questionnaires.
CANDO-3
اقرأ المزيد
– This study looks at women having chemotherapy before or after breast surgery. It measures body composition using a simple, non-invasive test called bioelectrical impedance. Researchers will record the type and dose of chemotherapy each patient receives, along with any side effects.
– The aim is to see whether body fat and muscle levels affect how patients respond to treatment. In particular, the study will explore whether higher or lower fat mass or fat-free mass can help predict the risk of more severe side effects during chemotherapy, helping improve care in the future.
PRIMETIME
اقرأ المزيد
– This study looks at whether some people with very low-risk breast cancer can safely skip radiotherapy after surgery. Radiotherapy is usually given to reduce the chance of cancer returning, but it can cause side effects. PRIMETIME uses a new risk score from lab tests on the removed cancer to identify patients whose chance of recurrence is very low. Those patients may avoid radiotherapy.
– The study also tested whether written and video information helps people feel more confident about their treatment decisions. Over 1,900 participants from 64 NHS hospitals in the UK took part.
TeaM
اقرأ المزيد
– The TeaM study looks at therapeutic mammaplasty (TM), a type of breast-conserving surgery that combines tumour removal with breast reduction or lift techniques. TM can help women avoid mastectomy while keeping a natural breast shape. This UK-wide study collects information on how often TM is done, the surgical techniques used, patient outcomes, and 30-day complications.
– It also examines how TM affects the timing of additional cancer treatments. The aim is to describe current practice, identify predictors of complications, and provide evidence to develop national guidelines and plan future research on TM.
POETIC-A
اقرأ المزيد
– This study looks at post-menopausal women with a common type of breast cancer to find those at higher risk of the cancer returning. Patients first receive hormone therapy before surgery, and their tumour response is measured. If the cancer remains active, they are considered higher risk. These patients are then treated with either standard hormone therapy alone or combined with an additional targeted drug called abemaciclib.
– The aim is to see if adding this drug improves outcomes and to identify which patients benefit most from extra treatment.
SENTINUS
اقرأ المزيد
– The SENTINUS study is testing a new, less invasive way to check if breast cancer has spread to the armpit lymph nodes. Instead of surgery, it uses contrast-enhanced ultrasound (CEUS) with tiny microbubbles to locate and biopsy the sentinel lymph nodes. The trial will see if imaging specialists can be trained to perform this reliably, how accurate the method is compared to standard surgery, and how satisfied patients and specialists are with the procedure.
– If successful, this could lead to a larger trial comparing CEUS to surgery, potentially reducing complications like infection and arm swelling.
EndoNET
اقرأ المزيد
– This study is a large clinical trial looking at a treatment called neoadjuvant endocrine therapy (NET) in post-menopausal women with breast cancer. NET is hormone treatment given before surgery. The trial aims to find out if giving this treatment first can make surgery easier or less extensive.
– It focuses on women with strongly hormone-sensitive (ER-positive) breast cancer who are not having chemotherapy or targeted HER2 treatment. By shrinking the cancer before surgery, doctors hope to reduce the amount of surgery needed and improve overall treatment outcomes for patients.
REI-EXCISE
اقرأ المزيد
– The REI-EXCISE study is testing a new technology called the iKnife to check if all cancer has been removed during breast-conserving surgery. Positive or close margins can increase the risk of cancer returning, and re-operations can cause delays, stress, and extra costs. This study uses rapid evaporative ionisation mass spectrometry to analyse the edges of the removed tissue in real time during surgery.
– The goal is to see how accurately the iKnife can identify whether margins are clear of cancer, which could reduce the need for additional surgery and improve outcomes for patients.
PEARL
اقرأ المزيد
– This study looks at how progesterone affects early breast cancer in premenopausal women. It tests whether adding progesterone (a natural hormone) to standard treatment with tamoxifen can slow cancer cell growth. Patients will receive either tamoxifen alone or tamoxifen with progesterone for a short period before surgery. Researchers will measure how active the cancer cells are before and after treatment using a marker called Ki67.
– The aim is to see if this combination can better reduce cancer growth and improve understanding of how hormones affect breast cancer.
PIONEER
اقرأ المزيد
– The Pioneer study is testing whether adding Megestrol Acetate to Letrozole before surgery can better slow the growth of early-stage breast cancer in postmenopausal women. Participants have ER-positive, HER2-negative breast cancer at least 1 cm in size. Over 15–19 days before surgery, women receive either Letrozole alone or Letrozole plus Megestrol Acetate at two different doses.
– The main goal is to see if this combination reduces cancer cell growth, measured by Ki67, a marker of proliferation, which may help improve understanding of how hormone therapies can work together to treat breast cancer.
LOLIPOP
اقرأ المزيد
– This study looks at long-term pain after breast cancer surgery, which affects more than one in four patients in the UK. It is testing whether giving a medicine called lidocaine during and shortly after surgery can reduce this pain. Lidocaine is given through a drip during the operation and sometimes for up to 24 hours after.
– The study will check if this reduces moderate or severe pain one year later. The UK part of the study also looks at whether this treatment is safe, effective, and good value for money in day-case surgery patients.
ComManDS
اقرأ المزيد
– Current guidelines recommend sentinel node biopsy (SNB) for all patients having a mastectomy for ductal carcinoma in situ (DCIS). This study reviews patients who need a second surgery (completion mastectomy) after breast-conserving surgery did not fully remove the DCIS.
– It aims to find how often invasive cancer or lymph node spread is discovered at this stage. Because both are expected to be rare, the study explores whether SNB can be safely avoided. It will also identify risk factors and help improve future guidelines for managing lymph nodes in these patients.
NeST
اقرأ المزيد
– The NeST study is a UK-wide audit examining how neoadjuvant systemic therapies (NST) are used to treat breast cancer before surgery. It will collect information on when NST is given, what treatments are used, how response is monitored, and how surgery decisions are made for the breast and armpit. The study also looks at the use of additional treatments, like radiotherapy or systemic therapy, after NST, and records how well patients respond to treatment.
– The goal is to identify current practice, measure outcomes, and develop national guidelines for using NST safely and effectively across the UK.
LORIS
اقرأ المزيد
– This study looks at whether some women with low-risk ductal carcinoma in situ (DCIS) can safely avoid surgery. Currently, all DCIS is treated with surgery, even though some cases may never develop into harmful cancer. This can lead to unnecessary treatment. The trial compares standard surgery with active monitoring, where patients are closely followed without immediate treatment.
– The aim is to see if monitoring is just as safe as surgery in preventing invasive breast cancer. The results will help women make more informed choices about their treatment options.
SMALL
اقرأ المزيد
– This large clinical trial looks at whether a less invasive treatment can replace standard surgery for small breast cancers found through screening. It compares usual surgery with a technique called vacuum-assisted excision (VAE), which removes the cancer using a needle.
– The study includes 800 patients across the UK and will follow them for 5 years. Researchers will check if VAE is as safe, whether cancer returns, and if more procedures are needed. The aim is to see if this simpler approach can reduce unnecessary surgery while still giving effective cancer treatment.
iBRA2
اقرأ المزيد
– The iBRA-2 study looks at how immediate breast reconstruction after mastectomy affects the timing of additional cancer treatments, like chemotherapy or radiotherapy. While reconstruction can improve body image and quality of life, complications after surgery may delay or prevent these treatments, which could affect survival. This national study collects data on complication rates, how often adjuvant therapy is needed, and whether it is delayed or missed due to surgery.
– The aim is to identify which patients are at risk, understand the impact on treatment, and provide high-quality information to help patients and healthcare teams make informed decisions.
MIBREAST
اقرأ المزيد
– This study looks at whether 3D imaging can help women feel more confident about their breast reconstruction results. Women will either see a 3D simulation of how their breasts may look after treatment or receive standard information. The study then asks how confident they feel about the expected outcome using a simple rating scale. By comparing both groups, researchers aim to understand if 3D images improve decision-making and expectations.
– It also explores how treatments like radiotherapy may affect final results and patient satisfaction with their reconstruction outcomes.
MAMMA
اقرأ المزيد
– This study looks at how breast infections (mastitis) and abscesses are managed across the UK and Ireland. Mastitis is common in breastfeeding women, and some develop abscesses that need treatment. Although guidelines recommend simple treatments like antibiotics and needle drainage, care varies widely. Some patients receive incorrect antibiotics, unnecessary surgery, or hospital admission. This can delay recovery, increase costs, and affect mothers and babies.
– The study aims to understand current practices, identify differences between hospitals, and improve guidelines to ensure safer, more effective, and consistent care for patients.
NOSTRA
اقرأ المزيد
– This study looks at whether a simple biopsy test can detect any remaining cancer after chemotherapy in patients with a specific type of early breast cancer. After treatment, patients usually have surgery to check for residual cancer.
– This study tests whether multiple ultrasound-guided biopsies of the treated area can identify any remaining cancer instead. It is a feasibility study across several centres, designed to help plan a larger future trial. The goal is to see if this less invasive approach could safely guide treatment decisions after chemotherapy.
OPTIMA
اقرأ المزيد
– This study looks at ways to reduce unnecessary chemotherapy in patients with early breast cancer that is hormone-sensitive and HER2-negative. Currently, many patients receive chemotherapy even if they may not benefit from it.
– The trial compares standard treatment with a test called Prosigna, which helps assess how likely the cancer is to return. Patients with higher-risk scores receive chemotherapy, while most with lower-risk scores can safely have hormone therapy alone. The aim is to find a safer, more personalised approach to treatment while maintaining good outcomes and reducing side effects and costs.
MARECA
اقرأ المزيد
– This study looks at breast cancer that comes back in the same area after treatment, called locoregional recurrence (LRR). Although treatments have improved, some patients still develop this type of recurrence. There is limited guidance on the best way to manage it. The study will collect information across the UK to understand how often LRR occurs, how it is treated, and patient outcomes.
– It will also look at risk factors and whether the recurrence is a return of the original cancer or a new cancer, helping improve future treatment decisions.
PRADA-II
اقرأ المزيد
– This study looks at the timing of radiotherapy for women having mastectomy and breast reconstruction. Normally, radiotherapy is given after surgery, which can cause complications, delays, or damage to the reconstruction. This research tests whether giving radiotherapy before surgery is safe, effective, and helps preserve the quality of the reconstruction.
– The study will include 450 patients across 26 NHS hospitals, comparing pre- and post-operative radiotherapy. The main goal is to see if earlier radiotherapy improves satisfaction with reconstruction at two years and to check whether recruiting and running this trial is feasible.
RESTORE B
اقرأ المزيد
– This study looks at immediate pre-pectoral breast reconstruction, a technique where implants are placed over the chest muscle. Many surgeons currently use mesh to support and shape the implant, but concerns about mesh safety have grown. This feasibility study aims to see if patients can be recruited to a future trial comparing reconstruction with and without mesh.
– It will also assess patient and surgeon views, safety, costs, and relevant outcomes. The findings will help design a larger trial to determine whether using mesh is necessary and safe in this type of breast reconstruction.
TADPOLE
اقرأ المزيد
– This study looks at whether a less extensive operation can safely replace full lymph node removal in some breast cancer patients. Currently, many patients have all lymph nodes in the armpit removed, which can cause long-term problems like swelling, pain, and reduced shoulder movement. The study compares this standard surgery with a more targeted approach called targeted axillary dissection (TAD), which removes only the affected nodes.
– The aim is to see if TAD can reduce complications like lymphoedema while still effectively controlling cancer and maintaining good long-term outcomes for patients.
PerfAct Study
اقرأ المزيد
– This study examines how surgical tools affect the safety of skin flaps during mastectomy with immediate breast reconstruction. Retractors, commonly used to hold tissue during surgery, may reduce blood flow and increase the risk of complications. The study compares two methods: using retractors versus a gentler technique with fingers first, followed by retractors.
– Blood flow in the skin flap is measured using a special dye (ICG) to see how each method affects perfusion. The goal is to provide evidence on safer surgical practices and help reduce complications in breast reconstruction.
Pre-BRA
اقرأ المزيد
– This study looks at a new method of breast reconstruction called pre-pectoral reconstruction, where the implant is placed in front of the chest muscle and fully covered with mesh. This may cause less pain and give a more natural result compared to the standard method under the muscle, but it has not been fully tested.
– The study will track outcomes like infections, hospital readmissions, and additional surgeries to assess safety. It also aims to prepare for a future larger trial to compare this new approach with standard reconstruction more thoroughly.
SWEET
اقرأ المزيد
– The SWEET trial is testing a support program to help women with early breast cancer stick to their hormone therapy after surgery. Many women stop or take their treatment inconsistently, which increases the risk of cancer returning. The program, called HT&Me, offers face-to-face or remote consultations and a web app to answer questions and support adherence.
– The study will recruit 1,460 patients, with half receiving standard care and half receiving HT&Me plus standard care. The main goals are to see if the program improves adherence and quality of life and whether it is cost-effective.
ANTHEM Study
اقرأ المزيد
– This study is exploring whether a type of breast-conserving surgery called oncoplastic surgery could be a good alternative to mastectomy. This approach combines cancer removal with plastic surgery techniques to improve appearance and help more women keep their breast. Currently, many women still need mastectomy, and not all have reconstruction.
– This study aims to see if a larger future trial is possible to compare these options. It will also look at patient outcomes, costs, and how women make decisions about their surgery, to help improve care and support in the future.
PartBreCon-Pro Study
اقرأ المزيد
– This study looks at a type of breast reconstruction called a chest wall perforator flap (CWPF), used after breast-conserving surgery for early breast cancer. It collects information from multiple hospitals to understand how safe and effective this procedure is. Researchers will record patient details, surgical results, complications, and any further operations.
– They will also track cancer outcomes such as recurrence and survival, and review radiotherapy use. In addition, patients will complete questionnaires about their recovery, satisfaction, and shoulder function to help assess overall results and improve future standards of care.
The AVOID study
اقرأ المزيد
– This audit aims to improve how doctors decide when lymph nodes in the underarm need a needle biopsy. It looks at the thickness of the lymph node lining (cortex) and how this is used across the UK. Hospitals are sharing their current practices and data from patients with confirmed breast cancer, including both normal and cancerous biopsy results.
– By collecting this information, the study hopes to create a clear national guideline. This will help ensure consistent care, support future research, and reduce unnecessary treatments while still identifying patients who need further care.
HER2-RADiCAL
اقرأ المزيد
– This study looks at patients with HER2-positive early breast cancer who have had chemotherapy and targeted treatment before surgery, and no cancer was found at surgery. These patients are considered lower risk. The study tests whether treatment can be safely reduced. Patients will continue trastuzumab to complete about 6 months of treatment but will not receive further pertuzumab or additional chemotherapy.
– Other treatments, like radiotherapy and hormone therapy, will continue as usual. The aim is to see if giving less treatment is still effective for patients whose cancer has responded very well.
Three Pillars Study
اقرأ المزيد
– This study is testing a combination of treatments given before surgery for post-menopausal women with a specific type of early breast cancer that is hormone receptor-positive and HER2-positive. The treatment includes targeted therapy and hormone therapy drugs. It is an open-label trial, meaning both doctors and patients know what treatment is being given.
– The main aim is to see how many patients have no remaining cancer found at surgery after 24 weeks of treatment. This helps researchers understand how effective this combination is in shrinking or removing the cancer before surgery.
MIAMI Controlled Trial
اقرأ المزيد
– The MIAMI study explores whether women with multiple cancers in the same breast can safely avoid mastectomy by having therapeutic mammoplasty, a breast-conserving surgery. The trial will compare local cancer control, quality of life, satisfaction with breast appearance, and surgery costs between the two approaches. This feasibility study will assess whether enough patients can be identified, agree to participate, and follow the assigned treatment.
– Participants will be randomly assigned to either therapeutic mammoplasty or mastectomy. The results will help plan a larger trial to determine if breast-conserving surgery is a safe and effective alternative for these patients.
NAC-AX Delphi Consensus Study
اقرأ المزيد
– This study looks at how best to manage lymph nodes in patients with breast cancer who receive chemotherapy before surgery. After treatment, it can be difficult to check if cancer is still in the lymph nodes, and current methods are not always accurate. New techniques that mark and remove specific lymph nodes may improve results. However, practice varies between hospitals.
– This study brings together experts to agree on the safest and most effective approach. The goal is to create clear international guidelines to improve care and outcomes for patients in the future.
Understanding the influence of age
اقرأ المزيد
– This study explores whether age affects treatment decisions for women with breast cancer. Older patients often have worse outcomes, and evidence suggests that clinicians may not always follow guidelines for them, possibly due to assumptions about age and frailty. Breast cancer surgeons, trainees, and nurses are being recruited to examine how age influences their treatment recommendations.
– The study aims to find out whether a patient’s age independently affects decisions and whether age-related beliefs or assumptions are linked to the treatments suggested, helping to improve care and outcomes for older women with breast cancer.
Bridging The Age Gap (BTAG)
اقرأ المزيد
– The Age Gap study looks at breast cancer in women over 70, who often receive different treatments and have worse outcomes than younger women. Treatment decisions are sometimes changed due to age or frailty, but there is little evidence on when this is necessary. This large study of over 3,000 women collects information on health, fitness, cancer type, and treatment to identify which patients benefit most from surgery versus hormone therapy.
– The study will develop a scoring system and an online tool to help doctors and patients make informed, personalised treatment decisions for older women with breast cancer.
Best-BRA Study
اقرأ المزيد
– This study tests whether it is possible to run a larger trial comparing two types of implant-based breast reconstruction: under the chest muscle (subpectoral) or over the muscle (pre-pectoral). Implant reconstruction is the most common breast reconstruction in the UK, but there is limited evidence on which method is best. The pilot study will recruit patients from breast and plastic surgery units, assess how many agree to participate, and collect safety, patient-reported, and cost data.
– It will also use a recruitment support program to improve patient participation and inform a future large-scale trial.